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Multiple Endpoints

Chemicals are listed based on one of multiple possible hazard endpoints.

This category is used when a listing agency provides a range of possible endpoints that may apply to the chemical. For example, ChemSec's SIN list has a category "CMR - Carcinogen, Mutagen &/or Reproductive Toxicant" whose chemcials could have any or all of those hazards. Since we don't know which specific endpoints apply for each chemical, we mark this sublist and others like it as "Multiple."

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Hazard lists affecting this endpoint

Hazards affecting Multiple Endpoints
Hazard List Hazard Rating and Description GREENSCREEN® HPD C2C
EU - ESIS PBT
Very high hazard High confidence
Fulfills PBT Criteria - Action Deferred Priority List Multiple Endpoints (Red)
EU - ESIS PBT
Very high hazard High confidence
PBT & POP Priority List Multiple Endpoints (Red)
EU - ESIS PBT
Very high hazard High confidence
PBT & vPvB Priority List Multiple Endpoints (Red)
EU - ESIS PBT
Very high hazard High confidence
PBT & vPvB & POP Priority List Multiple Endpoints (Red)
US EPA - Priority PBTs (NWMP)
Very high hazard High confidence
Priority PBT Priority List Multiple Endpoints (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
High hazard High confidence
H360FD - May damage fertility. May damage the unborn child [Reproductive toxicity - Category 1A or 1B] Priority List Multiple Endpoints (Red)
EU - SVHC List
High hazard High confidence
Equivalent Concern - Candidate List Priority List
EU - SVHC List
High hazard High confidence
Equivalent Concern - Candidate List: Systemic Toxicity/Organ Effects (Repeated Exposure) Priority List
EU - GHS (H-Statements) Annex 6 Table 3-1
High hazard High confidence
H304 - May be fatal if swallowed and enters airways [Aspiration hazard - Category 1] Priority List Inhalative Toxicity (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
Moderate hazard High confidence
H361 - Suspected of damaging fertility or the unborn child [Reproductive toxicity - Category 2] Priority List Multiple Endpoints (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
Moderate hazard High confidence
H361fd - Suspected of damaging fertility. Suspected of damaging the unborn child [Reproductive toxicity - Category 2] Priority List Multiple Endpoints (Red)
EU - Annex VI CMRs
High hazard Low confidence
Reproductive Toxicity - Category 1A Priority List Multiple Endpoints (Red)
EU - Annex VI CMRs
High hazard Low confidence
Reproductive Toxicity - Category 1B Priority List Multiple Endpoints (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
High hazard Low confidence
H360 - May damage fertility or the unborn child [Reproductive toxicity - Category 1A or 1B] Priority List Reproductive Toxicity (Repro + Dev) (Red)
EU - REACH Annex XVII CMRs
High hazard Low confidence
Reproductive toxicants: Category 1A Priority List Reproductive Toxicity (Repro + Dev) (Red)
EU - REACH Annex XVII CMRs
High hazard Low confidence
Reproductive toxicants: Category 1B Priority List Reproductive Toxicity (Repro + Dev) (Red)
EU - SVHC List
High hazard Low confidence
Toxic to reproduction - Banned unless Authorised Priority List Multiple Endpoints (Red)
EU - SVHC List
High hazard Low confidence
Toxic to reproduction - Candidate list Priority List Reproductive Toxicity (Repro + Dev)
EU - SVHC List
High hazard Low confidence
Toxic to reproduction - Prioritized for listing Priority List Reproductive Toxicity (Repro + Dev)
MAK
High hazard Low confidence
Sensitizing Substance Sah - Danger of airway & skin sensitization Priority List Multiple Endpoints (Red)
MAK
High hazard Low confidence
Sensitizing Substance SP - Danger of photocontact sensitization Priority List Multiple Endpoints (Red)
GHS - Japan
High to moderate hazard Low confidence
H317 - May cause an allergic skin reaction [Skin Sensitization - Category 1A] Skin and Respiratory Sensitization (Red)
GHS - Japan
High to moderate hazard Low confidence
H317 - May cause an allergic skin reaction [Skin Sensitization - Category 1B] Skin and Respiratory Sensitization (Red)
EU - Annex VI CMRs
Moderate hazard Low confidence
Reproductive Toxicity - Category 2 Priority List Multiple Endpoints (Red)
ChemSec - SIN List
Very high hazard Low confidence
PBT / vPvB (Persistent, Bioaccumulative, & Toxic / very Persistent & very Bioaccumulative) Priority List Multiple Endpoints (Red)
EU - ESIS PBT
Very high hazard Low confidence
PBT Priority List Multiple Endpoints (Red)
EU - ESIS PBT
Very high hazard Low confidence
POP (Persistent Organic Pollutant) Priority List Multiple Endpoints (Red)
GHS - New Zealand
Very high hazard Low confidence
Hazardous to the aquatic environment - acute category 1 Priority List Acute Aquatic Toxicity (Fish, Invertibrates, and/or Algae)
GHS - New Zealand
Very high hazard Low confidence
Hazardous to the aquatic environment - chronic category 1 Priority List Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae)
GHS - New Zealand
Very high hazard Low confidence
Hazardous to the aquatic environment - chronic category 2 Priority List Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae)
GHS - Japan
Very high hazard Low confidence
H370 - Causes damage to organs [Specific target organs/systemic toxicity following single exposure - Category 1] Priority List Oral, Dermal, and/or Inhalative Toxicity (Red)
GHS - Korea
Very high hazard Low confidence
H370 - Causes damage to organs [Specific target organ toxicity - Single exposure - Category 1] Priority List Oral, Dermal, and/or Inhalative Toxicity (Red)
GHS - Malaysia
Very high hazard Low confidence
H370 - Causes damage to organs [Specific target organ toxicity - single exposure - Category 1] Priority List Oral, Dermal, and/or Inhalative Toxicity (Red)
EC - CEPA DSL
High hazard Low confidence
Persistent, Bioaccumulative and inherently Toxic (PBiTE) to the Environment (based on aquatic organisms) Priority List Multiple Endpoints (Red)
EC - CEPA DSL
High hazard Low confidence
Persistent, Bioaccumulative and inherently Toxic (PBiTH) to humans Priority List Multiple Endpoints (Red)
GHS - Australia
High hazard Low confidence
H360FD - May damage fertility. May damage the unborn child [Reproductive toxicity - Category 1A or 1B] Priority List Multiple Endpoints (Red)
GHS - New Zealand
High hazard Low confidence
Hazardous to the aquatic environment - chronic category 3 Priority List Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae)
OSPAR - Priority PBTs & EDs & equivalent concern
High hazard Low confidence
PBT - Substance of Possible Concern (Sections B&C) Priority List
GHS - Australia
High hazard Low confidence
H304 - May be fatal if swallowed and enters airways [Aspiration hazard - Category 1] Priority List Inhalative Toxicity (Red)
GHS - Japan
High hazard Low confidence
H305 - May be harmful if swallowed and enters airways [Aspiration hazard - Category 2] Priority List
GHS - Japan
High hazard Low confidence
H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled [Respiratory sensitization - Category 1A] Priority List Skin and Respiratory Sensitization (Red)
GHS - Japan
High hazard Low confidence
H371 - May cause damage to organs [Specific target organs/systemic toxicity following single exposure - Category 2] Priority List Oral, Dermal, and/or Inhalative Toxicity (Yellow)
GHS - Japan
High hazard Low confidence
H372 - Causes damage to organs through prolonged or repeated exposure [Specific target organs/systemic toxicity following repeated exposure - Category 1] Priority List Oral, Dermal, and/or Inhalative Toxicity (Red)
GHS - Korea
High hazard Low confidence
H372 - Causes damage to organs through prolonged or repeated exposure [Specific target organ toxicity - Repeated exposure - Category 1] Priority List Oral, Dermal, and/or Inhalative Toxicity (Red)
GHS - Malaysia
High hazard Low confidence
H304 - May be fatal if swallowed and enters airways [Aspiration hazard - Category 1] Priority List Inhalative Toxicity (Red)
GHS - Malaysia
High hazard Low confidence
H372 - Causes damage to organs through prolonged or repeated exposure [Specific target organ toxicity - repeated exposure - Category 1] Priority List Oral, Dermal, and/or Inhalative Toxicity (Red)
GHS - Malaysia
High hazard Low confidence
H410 - Very toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 1] Priority List Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
GHS - New Zealand
High hazard Low confidence
Specific target organ toxicity - repeated exposure category 1 Priority List Other (Human Health)
GHS - New Zealand
High hazard Low confidence
Specific target organ toxicity - single exposure category 1 Priority List Other (Human Health)
GHS - Malaysia
High hazard Low confidence
H411 - Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 2] Priority List Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
GHS - Australia
Moderate hazard Low confidence
H361 - Suspected of damaging fertility or the unborn child [Reproductive toxicity - Category 2] Priority List Multiple Endpoints (Red)
GHS - Australia
Moderate hazard Low confidence
H361fd - Suspected of damaging fertility. Suspected of damaging the unborn child [Reproductive toxicity - Category 2] Priority List Multiple Endpoints (Red)
GHS - Malaysia
Moderate hazard Low confidence
H361fd - Suspected of damaging fertility. Suspected of damaging the unborn child [Reproductive toxicity - Category 2] Priority List Multiple Endpoints (Red)
GHS - Australia
Moderate hazard Low confidence
H412 - Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 3] Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
GHS - Australia
Moderate hazard Low confidence
H413 - May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment (chronic) - Category 4] Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
GHS - Japan
Moderate hazard Low confidence
H373 - May cause damage to organs through prolonged or repeated exposure [Specific target organs/systemic toxicity following repeated exposure - Category 2] Oral, Dermal, and/or Inhalative Toxicity (Yellow)
GHS - Korea
Moderate hazard Low confidence
H373 - May cause damage to organs through prolonged or repeated exposure [Specific target organ toxicity - Repeated exposure - Category 2] Oral, Dermal, and/or Inhalative Toxicity (Yellow)
GHS - Malaysia
Moderate hazard Low confidence
H412 - Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 3] Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
GHS - New Zealand
Moderate hazard Low confidence
Hazardous to the aquatic environment - chronic category 4 Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae)
GHS - New Zealand
Moderate hazard Low confidence
Specific target organ toxicity - repeated exposure category 2 Other (Human Health)
GHS - New Zealand
Moderate hazard Low confidence
Specific target organ toxicity - single exposure category 2 Other (Human Health)
GHS - New Zealand
Moderate hazard Low confidence
Specific target organ toxicity - single exposure category 3 narcotic effects Other (Human Health)
EU - SVHC List
Unspecified hazard High confidence
PBT - Banned unless Authorised Priority List Multiple Endpoints (Red)
EU - SVHC List
Unspecified hazard High confidence
PBT - Candidate list Priority List Multiple Endpoints
EU - SVHC List
Unspecified hazard High confidence
PBT - Prioritized for listing Priority List Multiple Endpoints
EU - SVHC List
Unspecified hazard High confidence
vPvB - Candidate list Priority List Multiple Endpoints
EU - SVHC List
Unspecified hazard High confidence
vPvB - Banned unless Authorised Priority List Multiple Endpoints (Red)
EU - SVHC List
Unspecified hazard High confidence
vPvB - Prioritized for listing Priority List Multiple Endpoints
OSPAR - Priority PBTs & EDs & equivalent concern
Unspecified hazard High confidence
PBT - Chemical for Priority Action Priority List Multiple Endpoints (Red)
UNEP Stockholm Conv - Persistent Organic Pollutants
Unspecified hazard High confidence
Priority POP Priority List Multiple Endpoints (Red)
US EPA - Toxics Release Inventory PBTs
Unspecified hazard High confidence
PBT Priority List Multiple Endpoints (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
Unspecified hazard High confidence
H413 - May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment (chronic) - Category 4] Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
OSPAR - Priority PBTs & EDs & equivalent concern
Unspecified hazard High confidence
Equivalent concern - Chemical for Priority Action Priority List
EU - GHS (H-Statements) Annex 6 Table 3-1
Unspecified hazard Low confidence
H410 - Very toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 1] Priority List Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
Unspecified hazard Low confidence
H411 - Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 2] Priority List Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
Unspecified hazard Low confidence
H412 - Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 3] Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
GHS - Japan
Potential concern hazard Low confidence
H304 - May be fatal if swallowed and enters airways [Aspiration hazard - Category 1] Inhalative Toxicity (Red)
GHS - Korea
Potential concern hazard Low confidence
H304 - May be fatal if swallowed and enters airways [Aspiration hazard - Category 1] Inhalative Toxicity (Red)
EU - ESIS PBT
Unspecified hazard Low confidence
vPvB Priority List Multiple Endpoints (Red)
OR DEQ - Priority Persistent Pollutants
Unspecified hazard Low confidence
Priority Persistent Pollutant - Tier 1 Priority List Multiple Endpoints (Red)
OR DEQ - Priority Persistent Pollutants
Unspecified hazard Low confidence
Priority Persistent Pollutant - Tier 2 Legacy Persistent Pollutants Priority List Multiple Endpoints (Red)
WA DoE - PBT
Unspecified hazard Low confidence
PBT Priority List Multiple Endpoints (Red)
OSPAR - Priority PBTs & EDs & equivalent concern
Unspecified hazard Low confidence
PBT - Substance of Possible Concern Priority List Multiple Endpoints (Red)
GHS - Australia
Unspecified hazard Low confidence
H410 - Very toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 1] Priority List Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
GHS - Japan
Unspecified hazard Low confidence
H410 - Very toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 1] Priority List Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae)
GHS - Japan
Unspecified hazard Low confidence
H411 - Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 2] Priority List Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae)
GHS - Australia
Unspecified hazard Low confidence
H411 - Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 2] Priority List Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
GHS - Japan
Unspecified hazard Low confidence
H412 - Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 3] Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae)
GHS - Korea
Unspecified hazard Low confidence
H410 - Very toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 1] Priority List Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
GHS - Korea
Unspecified hazard Low confidence
H411 - Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 2] Priority List Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
GHS - Korea
Unspecified hazard Low confidence
H412 - Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment (chronic) - Category 3] Chronic Aquatic Toxicity (Fish, Invertibrates, and/or Algae) (Red)
Québec CSST - WHMIS 1988
Unspecified hazard Low confidence
Class D2A - Very toxic material causing other toxic effects Multiple Endpoints (Red)
Québec CSST - WHMIS 1988
Unspecified hazard Low confidence
Class D2B - Toxic material causing other toxic effects Multiple Endpoints (Red)
Québec CSST - WHMIS 1988
Unspecified hazard Low confidence
Class E - Corrosive materials Multiple Endpoints (Red)
OSPAR - Priority PBTs & EDs & equivalent concern
Unspecified hazard Low confidence
Equivalent concern - Substance of Possible Concern Priority List
ChemSec - SIN List
Unspecified hazard Low confidence
CMR - Carcinogen, Mutagen &/or Reproductive Toxicant Priority List Multiple Endpoints (Red)
EC - CEPA DSL
Unspecified hazard Low confidence
Inherently Toxic in the Environment (iTE) Multiple Endpoints (Red)
EC - CEPA DSL
Unspecified hazard Low confidence
Inherently Toxic to Humans (iTH) Multiple Endpoints (Red)
EC - CEPA Toxic Substances (Sched 1)
Unspecified hazard Low confidence
CEPA Toxics Multiple Endpoints (Red)
German FEA - Substances Hazardous to Waters
Unspecified hazard Low confidence
Class 1 - Low Hazard to Waters Multiple Endpoints (Red)
German FEA - Substances Hazardous to Waters
Unspecified hazard Low confidence
Class 2 - Hazard to Waters Priority List Multiple Endpoints (Red)
German FEA - Substances Hazardous to Waters
Unspecified hazard Low confidence
Class 3 - Severe Hazard to Waters Priority List Multiple Endpoints (Red)
GHS - Australia
High hazard
H360 - May damage fertility or the unborn child [Reproductive toxicity - Category 1A or 1B] Reproductive Toxicity (Repro + Dev) (Red)
EHP - San Antonio Statement on BFRs & CFRs
Very high hazard
Flame retardant substance class of concern for PB&T & long range transport
UNEP Stockholm Conv - Persistent Organic Pollutants
Very high hazard
Persistent Organic Pollutant (POP) - proposed for listing Multiple Endpoints (Red)
US EPA - PPT Chemical Action Plans
Very high hazard
PBTs for Expedited Action to Reduce Risks
US EPA - Priority PBTs (PPT)
Very high hazard
Priority PBT Multiple Endpoints (Red)
UNEP Stockholm Conv - Persistent Organic Pollutants
High hazard
May degrade to PFOS - PBT under review for listing Multiple Endpoints (Red)
GHS - New Zealand
High hazard
Aspiration hazard category 1 Inhalative Toxicity
ChemSec - SIN List
Potential concern hazard
Reproductive and/or developmental
ChemSec - SIN List
Potential concern hazard
Equivalent Concern
EC - Virtual Elimination List
Potential concern hazard
Virtual Elimination List Multiple Endpoints
EU - ESIS PBT
Potential concern hazard
Not fulfilling PBT & vPvB criteria
EU - ESIS PBT
Potential concern hazard
Under PBT evaluation
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H304 - May be fatal if swallowed and enters airways (unverified) [Aspiration hazard - Category 1]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H360 - Suspected of / May damage fertility and/or the unborn child (unverified) [Reproductive toxicity - Category 1A or 1B]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H361 - Suspected of damaging fertility or the unborn child (unverified) [Reproductive toxicity - Category 2]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H410 - Very toxic to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 1]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H411 - Toxic to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 2]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H412 - Harmful to aquatic life with long lasting effects (unverified) [Hazardous to the aquatic environment (chronic) - Category 3]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H413 - May cause long lasting harmful effects to aquatic life (unverified) [Hazardous to the aquatic environment (chronic) - Category 4]