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Carcinogenicity

Ability to cause cancer or contribute to the development of cancer

GHS Definition (6th revised edition):

The term carcinogen denotes a substance or a mixture which induces cancer or increases its incidence. Substances and mixtures which have induced benign and malignant tumours in well performed experimental studies on animals are considered also to be presumed or suspected human carcinogens unless there is strong evidence that the mechanism of tumour formation is not relevant for humans.

Classification of a substance or mixture as posing a carcinogenic hazard is based on its inherent properties and does not provide information on the level of the human cancer risk which the use of the substance or mixture may represent.

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Hazard lists affecting this endpoint

Hazards affecting Carcinogenicity
Hazard List Hazard Rating and Description GREENSCREEN® HPD C2C
CA EPA - Prop 65
High hazard High confidence
Carcinogen Priority List Carcinogenicity (Red)
EU - Annex VI CMRs
High hazard High confidence
Carcinogen Category 1A - Known human Carcinogen based on human evidence Priority List Carcinogenicity (Red)
EU - Annex VI CMRs
High hazard High confidence
Carcinogen Category 1B - Presumed Carcinogen based on animal evidence Priority List Carcinogenicity (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
High hazard High confidence
H350 - May cause cancer [Carcinogenicity - Category 1A or 1B] Priority List Carcinogenicity (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
High hazard High confidence
H350i - May cause cancer by inhalation [Carcinogenicity - Category 1A or 1B] Priority List Carcinogenicity (Red)
EU - REACH Annex XVII CMRs
High hazard High confidence
Carcinogens: Category 1A Priority List Carcinogenicity (Red)
EU - REACH Annex XVII CMRs
High hazard High confidence
Carcinogens: Category 1B Priority List Carcinogenicity (Red)
EU - SVHC List
High hazard High confidence
Carcinogenic - Banned unless Authorised Priority List Carcinogenicity (Red)
EU - SVHC List
High hazard High confidence
Carcinogenic - Candidate list Priority List Carcinogenicity
EU - SVHC List
High hazard High confidence
Carcinogenic - Prioritized for listing Priority List Carcinogenicity
IARC
High hazard High confidence
Group 1 - Agent is Carcinogenic to humans Priority List Carcinogenicity (Red)
IARC
High hazard High confidence
Group 1 - Agent is carcinogenic to humans - inhaled from occupational sources Priority List Carcinogenicity (Red)
IARC
High hazard High confidence
Group 2A - Agent is probably Carcinogenic to humans Priority List Carcinogenicity (Red)
IARC
High hazard High confidence
Group 2A - Agent is probably carcinogenic to humans - inhaled from occupational sources Priority List Carcinogenicity (Red)
MAK
High hazard High confidence
Carcinogen Group 1 - Substances that cause cancer in man Priority List Carcinogenicity (Red)
MAK
High hazard High confidence
Carcinogen Group 2 - Considered to be carcinogenic for man Priority List Carcinogenicity (Red)
US CDC - Occupational Carcinogens
High hazard High confidence
Occupational Carcinogen Priority List Carcinogenicity (Red)
US EPA - IRIS Carcinogens
High hazard High confidence
(1986) Group A - Human Carcinogen Priority List Carcinogenicity (Red)
US EPA - IRIS Carcinogens
High hazard High confidence
(1986) Group B1 - Probable human Carcinogen Priority List Carcinogenicity (Red)
US EPA - IRIS Carcinogens
High hazard High confidence
(1986) Group B2 - Probable human Carcinogen Priority List Carcinogenicity (Red)
US EPA - IRIS Carcinogens
High hazard High confidence
(1996) Known/likely human Carcinogen Priority List Carcinogenicity (Red)
US EPA - IRIS Carcinogens
High hazard High confidence
(1999, 2005) Carcinogenic to humans Priority List Carcinogenicity (Red)
US EPA - IRIS Carcinogens
High hazard High confidence
(1999, 2005) Likely to be Carcinogenic to humans Priority List Carcinogenicity (Red)
US NIH - Report on Carcinogens
High hazard High confidence
Known to be a human Carcinogen Priority List Carcinogenicity (Red)
US NIH - Report on Carcinogens
High hazard High confidence
Reasonably Anticipated to be Human Carcinogen Priority List Carcinogenicity (Red)
US NIH - Report on Carcinogens
High hazard High confidence
Known to be Human Carcinogen (respirable size - occupational setting) Priority List Carcinogenicity (Red)
US NIH - Report on Carcinogens
High hazard High confidence
Reasonably Anticipated to be Human Carcinogen (respirable size - occupational setting) Priority List Carcinogenicity (Red)
EU - Annex VI CMRs
Moderate hazard High confidence
Carcinogen Category 2 - Suspected human Carcinogen Priority List Carcinogenicity (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
Moderate hazard High confidence
H351 - Suspected of causing cancer [Carcinogenicity - Category 2] Priority List Carcinogenicity (Red)
IARC
Moderate hazard High confidence
Group 2B - Possibly carcinogenic to humans Priority List Carcinogenicity (Red)
IARC
Moderate hazard High confidence
Group 2B - Possibly carcinogenic to humans - inhaled from occupational sources Priority List Carcinogenicity (Red)
MAK
Moderate hazard High confidence
Carcinogen Group 3A - Evidence of carcinogenic effects but not sufficient to establish MAK/BAT value Priority List Carcinogenicity (Red)
MAK
Moderate hazard High confidence
Carcinogen Group 3B - Evidence of carcinogenic effects but not sufficient for classification Priority List Carcinogenicity (Red)
MAK
Moderate hazard High confidence
Carcinogen Group 4 - Non-genotoxic carcinogen with low risk under MAK/BAT levels Priority List Carcinogenicity (Yellow)
MAK
Moderate hazard High confidence
Carcinogen Group 5 - Genotoxic carcinogen with very slight risk under MAK/BAT levels Priority List Carcinogenicity (Red)
US EPA - IRIS Carcinogens
Moderate hazard High confidence
(1986) Group C - Possible human Carcinogen Priority List Carcinogenicity (Red)
IARC
Low hazard High confidence
Group 4 - Agent is probably not carcinogenic to humans Carcinogenicity (Green)
US EPA - IRIS Carcinogens
Low hazard High confidence
(1986) Group E - Evidence of non-carcinogenicity for humans Carcinogenicity (Green)
CA EPA - Prop 65
High to moderate hazard Low confidence
Carcinogen - specific to chemical form or exposure route Priority List Carcinogenicity (Red)
US EPA - IRIS Carcinogens
Low hazard Low confidence
(1996, 1999, 2005) Not likely to be carcinogenic to humans Carcinogenicity (Green)
GHS - Australia
High hazard Low confidence
H350 - May cause cancer [Carcinogenicity - Category 1A or 1B] Priority List Carcinogenicity (Red)
GHS - Australia
High hazard Low confidence
H350i - May cause cancer by inhalation [Carcinogenicity - Category 1A or 1B] Priority List Carcinogenicity (Red)
GHS - Japan
High hazard Low confidence
H350 - May cause cancer [Carcinogenicity - Category 1A] Priority List Carcinogenicity (Red)
GHS - Japan
High hazard Low confidence
H350 - May cause cancer [Carcinogenicity - Category 1B] Priority List Carcinogenicity (Red)
GHS - Korea
High hazard Low confidence
H350 - May cause cancer [Carcinogenicity - Category 1] Priority List Carcinogenicity (Red)
GHS - Malaysia
High hazard Low confidence
H350 - May cause cancer [Carcinogenicity - Category 1A or 1B] Priority List Carcinogenicity (Red)
GHS - Malaysia
High hazard Low confidence
H350i - May cause cancer by inhalation [Carcinogenicity - Category 1A or 1B] Priority List Carcinogenicity (Red)
GHS - New Zealand
High hazard Low confidence
Carcinogenicity category 1 Priority List Carcinogenicity
GHS - Australia
Moderate hazard Low confidence
H351 - Suspected of causing cancer [Carcinogenicity - Category 2] Priority List Carcinogenicity (Red)
GHS - Japan
Moderate hazard Low confidence
H351 - Suspected of causing cancer [Carcinogenicity - Category 2] Priority List Carcinogenicity (Red)
GHS - Korea
Moderate hazard Low confidence
H351 - Suspected of causing cancer [Carcinogenicity - Category 2] Priority List Carcinogenicity (Red)
GHS - Malaysia
Moderate hazard Low confidence
H351 - Suspected of causing cancer [Carcinogenicity - Category 2] Priority List Carcinogenicity (Red)
GHS - New Zealand
Moderate hazard Low confidence
Carcinogenicity category 2 Priority List Carcinogenicity
US EPA - IRIS Carcinogens
High to low hazard Low confidence
(2005) Suggestive evidence of Carcinogenic potential Carcinogenicity (Red, Yellow, or Green)
IARC
High to low hazard Low confidence
Group 3 - Agent is not classifiable as to its carcinogenicity to humans Carcinogenicity (Red, Yellow, or Green)
US EPA - IRIS Carcinogens
High to low hazard Low confidence
(1986) Group D - Not classifiable as to human carcinogenicity Carcinogenicity (Red, Yellow, or Green)
US EPA - IRIS Carcinogens
High to low hazard Low confidence
(1999) Suggestive evidence of carcinogenicity Carcinogenicity (Red, Yellow, or Green)
US EPA - PPT Chemical Action Plans
High hazard
Known human carcinogen - TSCA Criteria met Carcinogenicity
US EPA - PPT Chemical Action Plans
High hazard
Probable human carcinogen - TSCA Criteria met Carcinogenicity
US EPA - PPT Chemical Action Plans
Moderate hazard
Limited evidence of carcinogenicity - TSCA Criteria met Carcinogenicity
US EPA - PPT Chemical Action Plans
Moderate hazard
Possible carcinogen - TSCA Criteria met Carcinogenicity
US EPA - PPT Chemical Action Plans
Moderate hazard
Potential carcinogenicity to specifc target organs - TSCA Criteria met Carcinogenicity
US EPA - IRIS Carcinogens
High to low hazard
(1996) Carcinogenic potential cannot be determined Carcinogenicity (Red, Yellow, or Green)
US EPA - IRIS Carcinogens
High to low hazard
(1999) Data are inadequate for an assessment of human carcinogenic potential Carcinogenicity (Red, Yellow, or Green)
US EPA - IRIS Carcinogens
High to low hazard
(2005) Inadequate information to assess carcinogenic potential Carcinogenicity (Red, Yellow, or Green)
CA EPA - Prop 65
Potential concern hazard
Carcinogen - Delisted
DK-EPA - Danish Advisory List
Potential concern hazard
Carc. 2; H351 - Suspected of causing cancer (modeled)
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H350 - May cause cancer (unverified) [Carcinogenicity - Category 1A or 1B]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H350i - May cause cancer by inhalation (unverified) [Carcinogenicity - Category 1A or 1B]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H351 - Suspected of causing cancer (unverified) [Carcinogenicity - Category 2]
Silent Spring - Breast Cancer Chemicals
Potential concern hazard
Chemicals that increased mammary gland tumors in animal studies Carcinogenicity