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Acute Mammalian Toxicity

Ability to be fatal on contact, ingestion, or inhalation for humans and other mammals.

GHS Definition (6th edition):

Acute toxicity refers to those adverse effects occurring following oral or dermal administration of a single dose of a substance, or multiple doses given within 24 hours, or an inhalation exposure of 4 hours.

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Hazard lists affecting this endpoint

Hazards affecting Acute Mammalian Toxicity
Hazard List Hazard Rating and Description GREENSCREEN® HPD C2C
EU - GHS (H-Statements) Annex 6 Table 3-1
Very high hazard High confidence
H300 - Fatal if swallowed [Acute toxicity (oral) - Category 1 or 2] Priority List Oral Toxicity (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
Very high hazard High confidence
H310 - Fatal in contact with skin [Acute toxicity (dermal) - Category 1 or 2] Priority List Dermal Toxicity (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
Very high hazard High confidence
H330 - Fatal if inhaled [Acute toxicity (inhalation) - Category 1 or 2] Priority List Inhalative Toxicity (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
High hazard High confidence
H311 - Toxic in contact with skin [Acute toxicity (dermal) - Category 3] Priority List Dermal Toxicity (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
High hazard High confidence
H301 - Toxic if swallowed [Acute toxicity (oral) - Category 3] Priority List Oral Toxicity (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
High hazard High confidence
H331 - Toxic if inhaled [Acute toxicity (inhalation) - Category 3] Priority List Inhalative Toxicity (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
Moderate hazard High confidence
H302 - Harmful if swallowed [Acute toxicity (oral) - Category 4] Oral Toxicity (Red or Yellow)
EU - GHS (H-Statements) Annex 6 Table 3-1
Moderate hazard High confidence
H312 - Harmful in contact with skin [Acute toxicity (dermal) - Category 4] Dermal Toxicity (Red or Yellow)
EU - GHS (H-Statements) Annex 6 Table 3-1
Moderate hazard High confidence
H332 - Harmful if inhaled [Acute toxicity (inhalation) - Category 4] Inhalative Toxicity (Red or Yellow)
US EPA - EPCRA Extremely Hazardous Substances
Very high to high hazard Low confidence
Extremely Hazardous Substances Priority List Oral, Dermal, and/or Inhalative Toxicity (Red)
GHS - Korea
Very high hazard Low confidence
H310 - Fatal in contact with skin [Acute toxicity (dermal) - Category 2] Priority List Dermal Toxicity (Red)
GHS - New Zealand
Very high hazard Low confidence
Acute dermal toxicity category 1 Priority List Oral, Dermal, and/or Inhalative Toxicity
GHS - New Zealand
Very high hazard Low confidence
Acute dermal toxicity category 2 Priority List Oral, Dermal, and/or Inhalative Toxicity
GHS - New Zealand
Very high hazard Low confidence
Acute inhalation toxicity category 1 Priority List Oral, Dermal, and/or Inhalative Toxicity
GHS - New Zealand
Very high hazard Low confidence
Acute inhalation toxicity category 2 Priority List Oral, Dermal, and/or Inhalative Toxicity
GHS - New Zealand
Very high hazard Low confidence
Acute oral toxicity category 1 Priority List Oral, Dermal, and/or Inhalative Toxicity
GHS - New Zealand
Very high hazard Low confidence
Acute oral toxicity category 2 Priority List Oral, Dermal, and/or Inhalative Toxicity
GHS - Australia
Very high hazard Low confidence
H300 - Fatal if swallowed [Acute toxicity (oral) - Category 1 or 2] Priority List Oral Toxicity (Red)
GHS - Australia
Very high hazard Low confidence
H310 - Fatal in contact with skin [Acute toxicity (dermal) - Category 1 or 2] Priority List Dermal Toxicity (Red)
GHS - Australia
Very high hazard Low confidence
H330 - Fatal if inhaled [Acute toxicity (inhalation) - Category 1 or 2] Priority List Inhalative Toxicity (Red)
GHS - Japan
Very high hazard Low confidence
H300 - Fatal if swallowed [Acute Toxicity (oral) - Category 1] Priority List Oral Toxicity (Red)
GHS - Japan
Very high hazard Low confidence
H300 - Fatal if swallowed [Acute Toxicity (oral) - Category 2] Priority List Oral Toxicity (Red)
GHS - Japan
Very high hazard Low confidence
H310 - Fatal in contact with skin [Acute Toxicity (dermal) - Category 1] Priority List Dermal Toxicity (Red)
GHS - Japan
Very high hazard Low confidence
H310 - Fatal in contact with skin [Acute Toxicity (dermal) - Category 2] Priority List Dermal Toxicity (Red)
GHS - Japan
Very high hazard Low confidence
H330 - Fatal if inhaled [Acute toxicity (inhalation: dust, mist) - Category 1] Priority List Inhalative Toxicity (Red)
GHS - Japan
Very high hazard Low confidence
H330 - Fatal if inhaled [Acute toxicity (inhalation: dust, mist) - Category 2] Priority List Inhalative Toxicity (Red)
GHS - Japan
Very high hazard Low confidence
H330 - Fatal if inhaled [Acute toxicity (inhalation: gas) - Category 1] Priority List Inhalative Toxicity (Red)
GHS - Japan
Very high hazard Low confidence
H330 - Fatal if inhaled [Acute toxicity (inhalation: gas) - Category 2] Priority List Inhalative Toxicity (Red)
GHS - Japan
Very high hazard Low confidence
H330 - Fatal if inhaled [Acute toxicity (inhalation: vapor) - Category 1] Priority List Inhalative Toxicity (Red)
GHS - Japan
Very high hazard Low confidence
H330 - Fatal if inhaled [Acute toxicity (inhalation: vapor) - Category 2] Priority List Inhalative Toxicity (Red)
GHS - Korea
Very high hazard Low confidence
H300 - Fatal if swallowed [Acute toxicity (oral) - Category 1] Priority List Oral Toxicity (Red)
GHS - Korea
Very high hazard Low confidence
H300 - Fatal if swallowed [Acute toxicity (oral) - Category 2] Priority List Oral Toxicity (Red)
GHS - Korea
Very high hazard Low confidence
H310 - Fatal in contact with skin [Acute toxicity (dermal) - Category 1] Priority List Dermal Toxicity (Red)
GHS - Korea
Very high hazard Low confidence
H330 - Fatal if inhaled [Acute toxicity (inhalation) - Category 1] Priority List Inhalative Toxicity (Red)
GHS - Korea
Very high hazard Low confidence
H330 - Fatal if inhaled [Acute toxicity (inhalation) - Category 2] Priority List Inhalative Toxicity (Red)
GHS - Malaysia
Very high hazard Low confidence
H300 - Fatal if swallowed [Acute toxicity (oral) - Category 1 or 2] Priority List Oral Toxicity (Red)
GHS - Malaysia
Very high hazard Low confidence
H310 - Fatal in contact with skin [Acute toxicity (dermal) - Category 1 or 2] Priority List Dermal Toxicity (Red)
GHS - Malaysia
Very high hazard Low confidence
H330 - Fatal if inhaled [Acute toxicity (inhalation) - Category 1 or 2] Priority List Inhalative Toxicity (Red)
GHS - Malaysia
Very high hazard Low confidence
H300 - Fatal if swallowed [Acute toxicity (oral) - Category 1 or 2] Priority List Oral Toxicity (Red)
Québec CSST - WHMIS 1988
Very high to high hazard Low confidence
Class D1A - Very toxic material causing immediate and serious toxic effects Priority List Oral, Dermal, and/or Inhalative Toxicity (Red)
GHS - Australia
Very high to high hazard Low confidence
H331 - Toxic if inhaled [Acute toxicity (inhalation) - Category 3] Priority List Inhalative Toxicity (Red)
GHS - Malaysia
Very high to high hazard Low confidence
H331 - Toxic if inhaled [Acute toxicity (inhalation) - Category 3] Priority List Inhalative Toxicity (Red)
GHS - Australia
High hazard Low confidence
H311 - Toxic in contact with skin [Acute toxicity (dermal) - Category 3] Priority List Dermal Toxicity (Red)
GHS - Korea
High hazard Low confidence
H301 - Toxic if swallowed [Acute toxicity (oral) - Category 3] Priority List Oral Toxicity (Red)
GHS - Korea
High hazard Low confidence
H311 - Toxic in contact with skin [Acute toxicity (dermal) - Category 3] Priority List Dermal Toxicity (Red)
GHS - Korea
High hazard Low confidence
H331 - Toxic if inhaled [Acute toxicity (inhalation) - Category 3] Priority List Inhalative Toxicity (Red)
GHS - Malaysia
High hazard Low confidence
H311 - Toxic in contact with skin [Acute toxicity (dermal) - Category 3] Priority List Dermal Toxicity (Red)
GHS - New Zealand
High hazard Low confidence
Acute dermal toxicity category 3 Priority List Oral, Dermal, and/or Inhalative Toxicity
GHS - New Zealand
High hazard Low confidence
Acute inhalation toxicity category 3 Priority List Oral, Dermal, and/or Inhalative Toxicity
GHS - New Zealand
High hazard Low confidence
Acute oral toxicity category 3 Priority List Oral, Dermal, and/or Inhalative Toxicity
GHS - Australia
High hazard Low confidence
H301 - Toxic if swallowed [Acute toxicity (oral) - Category 3] Priority List Oral Toxicity (Red)
GHS - Japan
High hazard Low confidence
H301 - Toxic if swallowed [Acute Toxicity (oral) - Category 3] Priority List Oral Toxicity (Red)
GHS - Japan
High hazard Low confidence
H311 - Toxic in contact with skin [Acute Toxicity (dermal) - Category 3] Priority List Dermal Toxicity (Red)
GHS - Japan
High hazard Low confidence
H331 - Toxic if inhaled [Acute toxicity (inhalation: dust, mist) - Category 3] Priority List Inhalative Toxicity (Red)
GHS - Japan
High hazard Low confidence
H331 - Toxic if inhaled [Acute toxicity (inhalation: gas) - Category 3] Priority List Inhalative Toxicity (Red)
GHS - Japan
High hazard Low confidence
H331 - Toxic if inhaled [Acute toxicity (inhalation: vapor) - Category 3] Priority List Inhalative Toxicity (Red)
GHS - Australia
High to moderate hazard Low confidence
H332 - Harmful if inhaled [Acute toxicity (inhalation) - Category 4] Inhalative Toxicity (Red or Yellow)
GHS - Malaysia
High to moderate hazard Low confidence
H332 - Harmful if inhaled [Acute toxicity (inhalation) - Category 4] Inhalative Toxicity (Red or Yellow)
GHS - Australia
Moderate hazard Low confidence
H302 - Harmful if swallowed [Acute toxicity (oral) - Category 4] Oral Toxicity (Red or Yellow)
GHS - Australia
Moderate hazard Low confidence
H312 - Harmful in contact with skin [Acute toxicity (dermal) - Category 4] Dermal Toxicity (Red or Yellow)
GHS - Japan
Moderate hazard Low confidence
H302 - Harmful if swallowed [Acute Toxicity (oral) - Category 4] Oral Toxicity (Yellow)
GHS - Japan
Moderate hazard Low confidence
H312 - Harmful in contact with skin [Acute Toxicity (dermal) - Category 4] Dermal Toxicity (Yellow)
GHS - Japan
Moderate hazard Low confidence
H332 - Harmful if inhaled [Acute toxicity (inhalation: dust, mist) - Category 4] Inhalative Toxicity (Yellow)
GHS - Japan
Moderate hazard Low confidence
H332 - Harmful if inhaled [Acute toxicity (inhalation: gas) - Category 4] Inhalative Toxicity (Yellow)
GHS - Japan
Moderate hazard Low confidence
H332 - Harmful if inhaled [Acute toxicity (inhalation: vapor) - Category 4] Inhalative Toxicity (Yellow)
GHS - Korea
Moderate hazard Low confidence
H302 - Harmful if swallowed [Acute toxicity (oral) - Category 4] Oral Toxicity (Yellow)
GHS - Korea
Moderate hazard Low confidence
H312 - Harmful in contact with skin [Acute toxicity (dermal) - Category 4] Dermal Toxicity (Yellow)
GHS - Korea
Moderate hazard Low confidence
H332 - Harmful if inhaled [Acute toxicity (inhalation) - Category 4] Inhalative Toxicity (Yellow)
GHS - Malaysia
Moderate hazard Low confidence
H302 - Harmful if swallowed [Acute toxicity (oral) - Category 4] Oral Toxicity (Red or Yellow)
GHS - Malaysia
Moderate hazard Low confidence
H312 - Harmful in contact with skin [Acute toxicity (dermal) - Category 4] Dermal Toxicity (Red or Yellow)
GHS - New Zealand
Moderate hazard Low confidence
Acute dermal toxicity category 4 Oral, Dermal, and/or Inhalative Toxicity
GHS - New Zealand
Moderate hazard Low confidence
Acute inhalation toxicity category 4 Oral, Dermal, and/or Inhalative Toxicity
GHS - New Zealand
Moderate hazard Low confidence
Acute oral toxicity category 4 Oral, Dermal, and/or Inhalative Toxicity
GHS - Japan
Low hazard Low confidence
H303 - May be harmful if swallowed [Acute Toxicity (oral) - Category 5] Oral Toxicity (Green)
GHS - Japan
Low hazard Low confidence
H313 - May be harmful in contact with skin [Acute Toxicity (dermal) - Category 5] Dermal Toxicity (Green)
GHS - Japan
Low hazard Low confidence
H333 - May be harmful if inhaled [Acute toxicity (inhalation: dust, mist) - Category 5] Inhalative Toxicity (Green)
GHS - Japan
Low hazard Low confidence
H333 - May be harmful if inhaled [Acute toxicity (inhalation: gas) - Category 5] Inhalative Toxicity (Green)
GHS - Japan
Low hazard Low confidence
H333 - May be harmful if inhaled [Acute toxicity (inhalation: vapor) - Category 5] Inhalative Toxicity (Green)
Québec CSST - WHMIS 1988
Very high to moderate hazard Low confidence
Class D1B - Toxic material causing immediate and serious toxic effects Oral, Dermal, and/or Inhalative Toxicity (Red or Yellow)
US EPA - PPT Chemical Action Plans
High hazard
Chronic mammalian toxicity - TSCA criteria met Oral, Dermal, and/or Inhalative Toxicity
US EPA - PPT Chemical Action Plans
High hazard
Chronic toxicity from inhalation exposures - TSCA Criteria met Inhalative Toxicity
US EPA - PPT Chemical Action Plans
Moderate hazard
Acute mammallian toxicity - TSCA Criteria met Oral, Dermal, and/or Inhalative Toxicity
US EPA - PPT Chemical Action Plans
Moderate hazard
Acute toxicity from inhalation exposures - TSCA Criteria met Inhalative Toxicity
EU - GHS (H-Statements) Annex 6 Table 3-1
Low hazard
H313 - May be harmful in contact with skin [Acute toxicity (dermal) - Category 5] Dermal Toxicity
EU - GHS (H-Statements) Annex 6 Table 3-1
Low hazard
H333 - May be harmful if inhaled [Acute toxicity (inhalation) - Category 5] Inhalative Toxicity
GHS - Australia
Low hazard
H313 - May be harmful in contact with skin [Acute toxicity (dermal) - Category 5] Dermal Toxicity
GHS - Australia
Low hazard
H333 - May be harmful if inhaled [Acute toxicity (inhalation) - Category 5] Inhalative Toxicity
US EPA - OPP - Registered Pesticides
Potential concern hazard
FIFRA Registered Pesticide
DK-EPA - Danish Advisory List
Potential concern hazard
Acute Tox. 1 - Fatal if swallowed (modeled)
DK-EPA - Danish Advisory List
Potential concern hazard
Acute Tox. 2 - Fatal if swallowed (modeled)
DK-EPA - Danish Advisory List
Potential concern hazard
Acute Tox. 3 - Toxic if swallowed (modeled)
DK-EPA - Danish Advisory List
Potential concern hazard
Acute Tox. 4 - Harmful if swallowed (modeled)
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H300 - Fatal if swallowed (unverified) [Acute toxicity (oral) - Category 1 or 2]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H301 - Toxic if swallowed (unverified) [Acute toxicity (oral) - Category 3]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H302 - Harmful if swallowed (unverified) [Acute toxicity (oral) - Category 4]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H310 - Fatal in contact with skin (unverified) [Acute toxicity (dermal) - Category 1 or 2]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H311 - Toxic in contact with skin (unverified) [Acute toxicity (dermal) - Category 3]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H312 - Harmful in contact with skin (unverified) [Acute toxicity (dermal) - Category 4]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H313 - May be harmful in contact with skin (unverified) [Acute toxicity (dermal) - Category 5]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H330 - Fatal if inhaled (unverified) [Acute toxicity (inhalation) - Category 1 or 2]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H331 - Toxic if inhaled (unverified) [Acute toxicity (inhalation) - Category 3]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H332 - Harmful if inhaled (unverified) [Acute toxicity (inhalation) - Category 4]
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H333 - May be harmful if inhaled (unverified) [Acute toxicity (inhalation) - Category 5]