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Developmental Toxicity incl. developmental neurotoxicity

Ability to cause harm to the developing child including birth defects, low birth weight and biological or behavioral problems that appear as the child grows.

GHS Definition (6th edition):

Included in [REPRODUCTIVE TOXICITY]. Adverse effects on development of the offspring. Taken in its widest sense, developmental toxicity includes any effect which interferes with normal development of the conceptus, either before or after birth, and resulting from exposure of either parent prior to conception, or exposure of the developing offspring during prenatal development, or postnatally, to the time of sexual maturation. However, it is considered that classification under the heading of developmental toxicity is primarily intended to provide a hazard warning for pregnant women and men and women of reproductive capacity. Therefore, for pragmatic purposes of classification, developmental toxicity essentially means adverse effects induced during pregnancy, or as a result of parental exposure. These effects can be manifested at any point in the life span of the organism. The major manifestations of developmental toxicity include death of the developing organism, structural abnormality, altered growth and functional deficiency.

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Hazard lists affecting this endpoint

Hazards affecting Developmental Toxicity incl. developmental neurotoxicity
Hazard List Hazard Rating and Description GREENSCREEN® HPD C2C
CA EPA - Prop 65
High hazard High confidence
Developmental toxicity Priority List Reproductive Toxicity (Repro + Dev) (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
High hazard High confidence
H360D - May damage the unborn child [Reproductive toxicity - Category 1A or 1B] Priority List Reproductive Toxicity (Repro + Dev) (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
High hazard High confidence
H360Df - May damage the unborn child. Suspected of damaging fertility [Reproductive toxicity - Category 1A or 1B] Priority List Reproductive Toxicity (Repro + Dev) (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
High hazard High confidence
H362 - May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation] Priority List Reproductive Toxicity (Repro + Dev) (Red)
US NIH - Reproductive & Developmental Monographs
High hazard High confidence
Clear Evidence of Adverse Effects - Developmental Toxicity Priority List Reproductive Toxicity (Repro + Dev) (Red, Yellow, or Green)
EU - GHS (H-Statements) Annex 6 Table 3-1
Moderate hazard High confidence
H360Fd - May damage fertility. Suspected of damaging the unborn child [Reproductive toxicity - Category 1A or 1B] Priority List Reproductive Toxicity (Repro + Dev) (Red)
EU - GHS (H-Statements) Annex 6 Table 3-1
Moderate hazard High confidence
H361d - Suspected of damaging the unborn child [Reproductive toxicity - Category 2] Priority List Reproductive Toxicity (Repro + Dev) (Red)
US NIH - Reproductive & Developmental Monographs
Low hazard High confidence
Clear Evidence of no Adverse Effects - Developmental Toxicity Reproductive Toxicity (Repro + Dev) (Green)
MAK
High to moderate hazard Low confidence
Pregnancy Risk Group A Priority List Reproductive Toxicity (Repro + Dev) (Red)
MAK
High to moderate hazard Low confidence
Pregnancy Risk Group B Priority List Reproductive Toxicity (Repro + Dev) (Red)
CA EPA - Prop 65
High to moderate hazard Low confidence
Developmental - specific to chemical form or exposure route Priority List Reproductive Toxicity (Repro + Dev) (Red)
US NIH - Reproductive & Developmental Monographs
High to moderate hazard Low confidence
Limited Evidence of Adverse Effects- Developmental Toxicity Priority List Reproductive Toxicity (Repro + Dev) (Red)
US NIH - Reproductive & Developmental Monographs
High to moderate hazard Low confidence
Some Evidence of Adverse Effects - Developmental Toxicity Priority List Reproductive Toxicity (Repro + Dev) (Red)
MAK
Moderate to low hazard Low confidence
Pregnancy Risk Group C Reproductive Toxicity (Repro + Dev) (Red, Yellow, or Green)
US NIH - Reproductive & Developmental Monographs
Moderate to low hazard Low confidence
Limited Evidence of no Adverse Effects - Developmental Toxicity Reproductive Toxicity (Repro + Dev) (Red, Yellow, or Green)
US NIH - Reproductive & Developmental Monographs
Moderate to low hazard Low confidence
Some Evidence of no Adverse Effects - Developmental Toxicity Reproductive Toxicity (Repro + Dev) (Red, Yellow, or Green)
GHS - Australia
High hazard Low confidence
H360D - May damage the unborn child [Reproductive toxicity - Category 1A or 1B] Priority List Reproductive Toxicity (Repro + Dev) (Red)
GHS - Australia
High hazard Low confidence
H360Df - May damage the unborn child. Suspected of damaging fertility [Reproductive toxicity - Category 1A or 1B] Priority List Reproductive Toxicity (Repro + Dev) (Red)
GHS - Australia
High hazard Low confidence
H362 - May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation] Priority List Reproductive Toxicity (Repro + Dev) (Red)
GHS - Japan
High hazard Low confidence
H362 - May cause harm to breast-fed children [Developmental Toxicity - May cause harm to breast-fed children] Priority List
GHS - Korea
High hazard Low confidence
H362 - May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation] Priority List
GHS - Malaysia
High hazard Low confidence
H360D - May damage the unborn child [Reproductive toxicity - Category 1A or 1B] Priority List Reproductive Toxicity (Repro + Dev) (Red)
GHS - Malaysia
High hazard Low confidence
H360Df - May damage the unborn child. Suspected of damaging fertility [Reproductive toxicity - Category 1A or 1B] Priority List Reproductive Toxicity (Repro + Dev) (Red)
GHS - Malaysia
High hazard Low confidence
H362 - May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation] Priority List Reproductive Toxicity (Repro + Dev) (Red)
GHS - New Zealand
High hazard Low confidence
Effects on or via lactation Priority List Reproductive Toxicity (Repro + Dev)
G&L - Neurotoxic Chemicals
High to moderate hazard Low confidence
Developmental Neurotoxicant Priority List Reproductive Toxicity (Repro + Dev) (Red)
G&L - Neurotoxic Chemicals
High to moderate hazard Low confidence
Developmental neurotoxicant (2014) Priority List Reproductive Toxicity (Repro + Dev)
GHS - Australia
Moderate hazard Low confidence
H360Fd - May damage fertility. Suspected of damaging the unborn child [Reproductive toxicity - Category 1A or 1B] Priority List Reproductive Toxicity (Repro + Dev) (Red)
GHS - Malaysia
Moderate hazard Low confidence
H360Fd - May damage fertility. Suspected of damaging the unborn child [Reproductive toxicity - Category 1A or 1B] Priority List Reproductive Toxicity (Repro + Dev) (Red)
GHS - Australia
Moderate hazard Low confidence
H361d - Suspected of damaging the unborn child [Reproductive toxicity - Category 2] Priority List Reproductive Toxicity (Repro + Dev) (Red)
GHS - Malaysia
Moderate hazard Low confidence
H361d - Suspected of damaging the unborn child [Reproductive toxicity - Category 2] Priority List Reproductive Toxicity (Repro + Dev) (Red)
MAK
High to low hazard Low confidence
Pregnancy Risk Group D Reproductive Toxicity (Repro + Dev) (Red, Yellow, or Green)
US NIH - Reproductive & Developmental Monographs
High to low hazard Low confidence
Insufficient Evidence for a Conclusion - Developmental Toxicity Reproductive Toxicity (Repro + Dev) (Red, Yellow, or Green)
Boyes - Neurotoxicants
High to low hazard Low confidence
Developmental Neurotoxicity Reproductive Toxicity (Repro + Dev) (Red, Yellow, or Green)
US EPA - PPT Chemical Action Plans
High hazard
Developmental Effects Reproductive Toxicity (Repro + Dev)
US EPA - PPT Chemical Action Plans
High hazard
Developmental toxicity - TSCA Criteria met Reproductive Toxicity (Repro + Dev)
US NIH - Reproductive & Developmental Monographs
Potential concern hazard
Developmental Toxicity - Nominated for study Reproductive Toxicity (Repro + Dev)
CA EPA - Prop 65
Potential concern hazard
Developmental toxicity - Delisted
EU - Manufacturer REACH hazard submissions
Potential concern hazard
H362 - May cause harm to breast-fed children (unverified) [Reproductive toxicity, effects on or via lactation]