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Ability to cause specific, non lethal but serious damage on contact or ingestion or inhalation, to one or more organs, such as the heart, lungs, liver, etc. distant from the point of entry of the toxicant.
[SPECIFIC TARGET ORGAN TOXICITY] (any exposure)
Specific, non lethal target organ toxicity arising from a single exposure or specific target organ toxicity arising from a repeated exposure includes all significant health effects that can impair function, both reversible and irreversible, immediate and/or delayed.
Other specific toxic effects, such as acute toxicity, serious eye damage/eye irritation, skin corrosion/irritation, respiratory or skin sensitization, carcinogenicity, germ cell mutagenicity, reproductive toxicity and aspiration toxicity are assessed separately in the GHS and consequently are not included here.
Assessment should take into consideration not only significant changes in a single organ or biological system but also generalized changes of a less severe nature involving several organs. Specific target organ toxicity can occur by any route that is relevant for humans, i.e. principally oral, dermal or inhalation.
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